Establishing the Safety and Efficacy of Reloxaliase in Patients With Enteric Hyperoxaluria

  • End date
    Nov 23, 2023
  • participants needed
  • sponsor
    Allena Pharmaceuticals
Updated on 23 September 2021


The purpose of this study is to determine the efficacy, durability and long-term safety of reloxaliase in patients with enteric hyperoxaluria.


This is a phase 3, global, multi-center, randomized, double-blind, placebo-controlled study. This study is designed to determine the short- and long-term efficacy of reloxaliase in terms of reducing urinary oxalate excretion and clinical benefits compared to placebo.

Condition Enteric Hyperoxaluria
Treatment Placebo, Reloxaliase
Clinical Study IdentifierNCT03847090
SponsorAllena Pharmaceuticals
Last Modified on23 September 2021


Yes No Not Sure

Inclusion Criteria

Provided informed consent
Age 18 years or older
Has an underlying enteric disorder associated with malabsorption with known or suspected history of hyperoxaluria (e.g., history of kidney stones or oxalate nephropathy)
Urinary oxalate 50 mg/24 hr
Has at least 1 documented kidney stone within 2 years

Exclusion Criteria

Acute renal failure or estimated glomerular filtration rate (eGFR) < 30 mL/minute/1.73 m2
Has a known genetic, congenital, or other cause of kidney stones
Unable or unwilling to discontinue Vitamin C supplementation >200mg daily
Cannot establish baseline kidney stone burden
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note