Last updated on September 2020

Study to Gather Information About the Proper Dosing of the Oral FXIa Inhibitor BAY 2433334 and to Compare the Safety of the Study Drug to Apixaban a Non-vitamin K Oral Anticoagulant (NOAC) in Patients With Irregular Heartbeat (Atrial Fibrillation) That Can Lead to Heart-related Complications.


Brief description of study

The purpose of this study is to try to find the best dose of the new drug BAY 2433334 to give to participants and to look at how well BAY 2433334 works in patients with irregular heartbeat (atrial fibrillation) that can lead to blood clots, stroke and other heart-related complications. In addition researchers want to compare the safety of the study drug to apixaban, a non-vitamin K oral anticoagulant (NOAC) in patients with atrial fibrillation. This study is also done to learn how the drug in this study moves into, through and out of the body. BAY 2433334, works by blocking a step of the blood clotting process in our body and thins the blood and is a so called oral FXIa inhibitor.

Apixaban, works by reducing the production of blood clotting factors in our body and thins the blood and is a so called non-vitamin K oral anticoagulant (NOAC). Thinning the blood can prevent you from blood clots which can cause a stroke.

Clinical Study Identifier: NCT04218266

Find a site near you

Start Over

UZ Antwerpen

Edegem, Belgium
  Connect »

VZW Emmaus

Mechelen, Belgium
  Connect »

AZ Delta

Roeselare, Belgium
  Connect »

Maastricht UMC

Maastricht, Netherlands
  Connect »

SU/ stra

Göteborg, Sweden
  Connect »

Skellefte Lasarett

Skellefteå, Sweden
  Connect »

Kantonsspital St. Gallen

St. Gallen, Switzerland
  Connect »

Kantonsspital Winterthur

Winterthur, Switzerland
  Connect »

Chesterfield Royal Hospital

Chesterfield, United Kingdom
  Connect »

Queen Elizabeth II Hospital

Welwyn Garden City, United Kingdom
  Connect »

Heart and Chest Hospital

Liverpool, United Kingdom
  Connect »

SU/ stra

Göteborg, Sweden
  Connect »

Skellefte Lasarett

Skellefteå, Sweden
  Connect »

St Richard's Hospital

Chichester, United Kingdom
  Connect »

SU/ stra

Göteborg, Sweden
  Connect »

Skellefte Lasarett

Skellefteå, Sweden
  Connect »

Tagore Medical Center

Balatonfured, Hungary
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.