Last updated on November 2019

Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: HIV | Cancer | Lymphoproliferative Disorder | HIV positive | HIV infection | human herpesvirus 8 | AIDS Vaccines | Kaposi's Sarcoma
  • Age: Between 12 - 65 Years
  • Gender: Male or Female


Age greater than or equal to 12 years.

Biopsy proven KSHV-associated MCD, confirmed in the Laboratory of Pathology, CCR.

Willing to give informed consent.

-A parent or guardian must be available for giving consent for pediatric subjects under 18 years of age.


Any abnormality that would be scored as NCI CTC Grade IV toxicity that is unrelated to HIV, its treatment, or to MCD that would preclude protocol treatment and/or observation only.

Presence of another malignancy requiring current treatment that would preclude the use of all of the study treatments or the ability to monitor the natural history of MCD untreated.

Pregnant women are excluded from this study as certain of the study agents have the potential for teratogenic effects

Any condition or set of circumstances that in the opinion of the investigators would make participation in this study unsafe or otherwise inappropriate for a given individual.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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