Imaging Modalities for Melanoma Screening and Diagnosis

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    OHSU Knight Cancer Institute
Updated on 21 October 2022
skin lesion
skin cancer
shave biopsy
Accepts healthy volunteers


This trial studies how well MoleMapper, Visiomed, and confocal microscopy work in screening participants for melanoma. Analyzing images (photographs) made with three different portable imaging systems may be as good as a visit to a dermatologist's office for finding melanomas before they can spread.



I. To assess the clinical utility of clinical images, digital dermoscopy images and in-vivo confocal microscopy for teledermatology.


I. To incorporate in vivo confocal images into the triage system in order to determine to what degree the information gathered in this modality changes the classification of a lesion assigned by a licensed dermatologist.


I. To assess the potential improvement of virtual patient triage when adding digital dermoscopy images to clinical images presented by patients to their provider (via e-visit or e-consult).


Participants undergo imaging of suspicious moles via smartphone application (app) MoleMapper/Sklip app/native smartphone camera app, digital dermoscopy, and confocal microscopy. Participants then receive lidocaine subcutaneously (SC) and undergo shave or punch biopsy of suspected melanomas.

After completion of study intervention, patients are followed up within 1 week.

Condition Cutaneous Melanoma, Melanocytic Nevus, Skin Carcinoma
Treatment Dermoscopy, lidocaine, Punch biopsy, Confocal Microscopy, Confocal Microscopy, Imaging Technique, Shave Biopsy
Clinical Study IdentifierNCT03699995
SponsorOHSU Knight Cancer Institute
Last Modified on21 October 2022


Yes No Not Sure

Inclusion Criteria

Persons who participate in the free skin cancer screening at the PDX Skincare Festival at Oregon Health & Science University (OHSU) in 2021/2022 (date pending) and are informed by a provider that they have a pigmented lesion for which a biopsy is recommended are potentially eligible to participate in this study
Persons who participate in the free skin cancer screening at the War on Skin Cancer event at OHSU in 2021/2022 (date pending) and are informed by a provider that they have a clinically benign or atypical nevi are eligible to participate in the imaging portion of this study. No biopsy will be offered to these participants
Persons of any race are eligible but we anticipate that most participants will be Non-Hispanic whites due to the prevalence of melanoma and other skin cancers in this group
Persons age 18-80 are eligible for the study
Only persons who can provide signed statement of informed consent will be enrolled
Persons who are identified in OHSU Dermatology clinics or through OHSU e-visit and e-consult platforms as having a skin lesion in need of a biopsy for skin cancer
Persons identified via the Melanoma Community Registry (MCR) (IRB approved: 00010561)

Exclusion Criteria

Allergy to the anesthetic (lidocaine)
Clear my responses

How to participate?

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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