Amantadine in Treating Cognitive & Motor Impairments in Adolescents and Adults With Cerebral Palsy

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    Columbia University
Updated on 24 January 2021
cognitive impairment


Cerebral palsy (CP) is a common childhood-onset disability associated with motor and cognitive impairments, however most research is focused on motor outcomes. The aim of this study is to determine the effects of Amantadine, a dopaminergic agonist, on cognitive function in adolescents and adults with CP.


CP is a heterogeneous condition due to injury to the developing brain. It is a condition that is often marked by both cognitive and motor disorders as well as increased prevalence of depression and anxiety. While most studies have focused on improving motor dysfunction, fewer have investigated cognitive impairments associated with CP. Dedicating a study to research the pharmacotherapeutic effect of Amantadine on cognitive function in adolescents and adults with cerebral palsy fills an important gap in development of a potential innovative treatment for cognitive deficits. The investigators hope to determine the effects of Amantadine on cognitive function in adolescents and adults with CP. The investigators will also evaluate secondary goals of improving gross and fine motor skills and mood.

Condition Cerebral Palsy, Cerebral Palsy (Pediatric), cerebral palsy (cp)
Treatment Amantadine hydrochloride
Clinical Study IdentifierNCT04273737
SponsorColumbia University
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

Diagnosed with Cerebral Palsy

Exclusion Criteria

Currently pregnant
Unstable seizure condition
Currently taking methadone
Currently taking other dopamine agonists
Currently taking anti-psychotic medication
Previously taken amantadine
Diagnosed with Chronic Kidney Disease (CKD)
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