Calcium Administration in Cardiac Surgery

  • End date
    Mar 30, 2022
  • participants needed
  • sponsor
    Meshalkin Research Institute of Pathology of Circulation
Updated on 28 January 2021
reperfusion injury
heart surgery
cardiopulmonary bypass
0.9% sodium chloride
acute pancreatitis
bypass surgery
inotropic agents


Termination of cardiopulmonary bypass is a critical step in any cardiac surgical procedure and requires a thorough planning. Debate about rationale of calcium administration during weaning of cardiopulmonary bypass has been conducted for several decades; however, a consensus has not been yet reached.

Perioperative hypocalcemia can develop because of haemodilution or calcium binding from heparin, albumin and citrate. Perioperative hypocalcemia is often complicated by development of arrhythmias, especially QT interval prolongation. Furthermore, low content of calcium can lead to vascular tone disorders, violation of neuromuscular transmission, altered hemostasis and heart failure, resistant to inotropic agents, especially in patients with concomitant cardiomyopathy.

On the other hand, hypercalcaemia is a dangerous complication in cardiac surgery. Among the fatal, but rather rare complications, there are acute pancreatitis and the phenomenon of the "stone heart", which is essentially a reperfusion injury of the myocardium caused by rapid calcium overload. Hypercalcaemia can also trigger rhythm disturbances, hypertension, increase systemic vascular resistance, reduce diastolic compliance and impair relaxation of the myocardium due to excessive calcium intake into the cardiomyocytes, cause coronary vasospasm and aggravate ischaemic myocardial damage, impair arterial graft blood flow during aortocoronary and mammary coronary bypass surgery.

To date, there is a lack of data indicating clinical efficacy of calcium administration before separation from CPB. Therefore, we designed this randomized controlled trial to test the hypothesis whether calcium administration at termination of CPB will reduce the need for inotropic support at the end of surgery.

Condition Thoracic Surgery, heart surgery, Cardiopulmonary Bypass, Cardiac Surgery, heart/lung bypass, cardiac operation
Treatment 0.9% sodium chloride, Calcium chloride
Clinical Study IdentifierNCT03772990
SponsorMeshalkin Research Institute of Pathology of Circulation
Last Modified on28 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Thoracic Surgery or Cardiac Surgery or Cardiopulmonary Bypass or heart surgery?
Do you have any of these conditions: heart surgery or heart/lung bypass or Thoracic Surgery or cardiac operation or Cardiopulmonary Bypass or Cardiac Surgery?
Do you have any of these conditions: Thoracic Surgery or Cardiac Surgery or Cardiopulmonary Bypass or heart/lung bypass or cardiac operation or heart surgery?
surgery under cardiopulmonary bypass
valve or valve surgery + CABG
age > 18 years
signed informed consent

Exclusion Criteria

emergency surgery
isolated aortic valve repair/replacement
planned (before surgery) blood transfusion
redo surgery
known allergy to the study drug
current enrollment into another RCT (in the last 30 days)
previous enrollment and randomization to ICARUS trial
liver cirrhosis (Child B or C)
transfusion during CPB
hypo- or hyperparathyreosis
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Phone Email

Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note