IORT in Local Advanced Laryngocarcinoma (ILAL)

  • End date
    Dec 1, 2023
  • participants needed
  • sponsor
    Tianjin First Central Hospital
Updated on 27 February 2022


The incidence of laryngeal cancer accounts for about 1 ~ 5% of the total body tumors. For the surgical treatment of laryngeal cancer, the development trend of laryngocarcinoma treatment is to improve the local control rate, preserve the laryngeal function of patients as far as possible, and improve the life quality of patients. The efficacy, safety and feasibility of intraoperative radiotherapy (IORT) in head and neck cancer has been demonstrated in multiple institutional (3-5) studies to optimize local control. It is still unclear whether IORT can improve the local control and have efficacy, safety and feasibility in clinic. The purpose of this study was to observe the efficacy, safety and feasibility of IORT in local advanced laryngocarcinoma .

Condition Laryngeal Neoplasms
Treatment Surgery, External radiotherapy, IORT
Clinical Study IdentifierNCT04278638
SponsorTianjin First Central Hospital
Last Modified on27 February 2022


Yes No Not Sure

Inclusion Criteria

adults over the age of 18
radiographic or pathological diagnosis of local advanced laryngocarcinoma (according to NCCN guidelines)
the expected survival time 3 months
sign informed consent for treatment and research with self-knowledge

Exclusion Criteria

there is distant metastasis
pregnant women
patients with CT/MRI contraindications
the patient fails to receive treatment and/or follow-up as scheduled
bad fluid and organ function decompensation
multiple primary cancers
patients participating in other trials
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