Fecal Microbiota Transplantation in aGvHD After ASCT

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    Medical University of Graz
Updated on 23 April 2022


Acute graft-versus-host-disease (aGvHD) is a typical complication after allogeneic hematopoetic stem cell transplantation (ASCT). About 30-60% of patients after ASCT are affected by aGvHD, which constitutes a relevant burden of morbidity and mortality in these patients.

Fecal microbiota transplantation (FMT) is a therapeutic concept to treat intestinal dysbiosis of various origin by infusion of the stool microbiota of a healthy donor into the gastrointestinal tract (GI) of a patient. FMT can be performed endoscopically by colonoscopic deployment of the donor microbiota into the patient´s caecum and terminal ileum.

Patients with gastrointestinal aGvHD (GI-aGvHD) are known to comprise a significant dysbiotic colonic microbiota that can be attenuated by FMT.

Condition Graft Versus Host Disease in GI Tract
Treatment Fecal Microbiota Transplantation
Clinical Study IdentifierNCT03819803
SponsorMedical University of Graz
Last Modified on23 April 2022


Yes No Not Sure

Inclusion Criteria

first episode of histologically confirmed, steroid-refractory GI-aGvHD
reduced bacterial diversity in the patient´s stool microbiota evidenced by 16s-rDNA measurement
eligibility for repeated colonoscopic procedures
informed consent

Exclusion Criteria

complications during a previous colonoscopy
recurrent episode of GI-aGvHD
lacking cardiopulmonary fitness for repeated colonoscopic procedures
septic infection
acute extraintestinal organ failure (excluding bone marrow)
mechanical ileus
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