| Is your age greater than or equal to 18 yrs? |
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| Are you male? |
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| Do you have Metastatic Hormone Sensitive Prostate Cancer? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Do you have any of these conditions: Do you have Metastatic Hormone Sensitive Prostate Cancer?? |
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| Male participants with histologically- or cytologically-confirmed adenocarcinoma of the prostate without small cell histology |
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| Has metastatic disease assessed by investigator and verified by BICR by either 2 bone lesions on bone scan and/or visceral disease by computed tomography/magnetic resonance imaging (CT/MRI) |
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| Willing to maintain continuous ADT with a LHRH agonists or antagonists during study treatment or have a history of bilateral orchiectomy |
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| Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 assessed within 10 days of randomization |
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| Participants receiving bone resorptive therapy (including, but not limited to, bisphosphonate or denosumab) must have been on stable doses prior to randomization |
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| Has adequate organ function |
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| Has provided newly obtained core or excisional biopsy (obtained within 12 months of screening) from soft tissue not previously irradiated (samples from tumors progressing in a prior site of radiation are allowed). Participants with bone only or bone predominant disease may provide a bone biopsy sample |
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| Male participants must agree to the following during the intervention period and for at least 120 days after the last dose of study intervention: Refrain from donating sperm PLUS either be abstinent from heterosexual intercourse and agree to remain abstinent OR agree to use contraception, unless confirmed to be azoospermic |
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| Male participants must agree to use male condom when engaging in any activity that allows for passage of ejaculate to another person of any sex |
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| Has a known additional malignancy that is progressing or has required active treatment in the last 3 years |
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| Has an active autoimmune disease that has required systemic treatment in past 2 years |
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| Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy |
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| Has undergone major surgery including local prostate intervention (excluding prostate biopsy) within 28 days prior to randomization and not recovered adequately from the toxicities and/or complications |
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| Has a gastrointestinal disorder affecting absorption or is unable to swallow tablets/capsules |
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| Has an active infection (including tuberculosis) requiring systemic therapy |
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| Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis |
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| Has known active human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) infection |
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| Has known or suspected central nervous system (CNS) metastases and/or carcinomatous meningitis |
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| Has a history of seizure or any condition that may predispose to seizure |
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| Has a history of loss of consciousness within 12 months of screening |
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| Has had myocardial infarction or uncontrolled angina within 6 months prior to randomization, or has New York Heart Association class III or IV congestive heart failure or a history of New York Heart Association class III or IV congestive heart failure |
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| Has hypotension (systolic blood pressure <86 millimeters of mercury [mmHg]) or uncontrolled hypertension (systolic blood pressure >170 mmHg or diastolic blood pressure >105 mmHg) at the screening visit |
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| Has a history of clinically significant ventricular arrhythmias |
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| Has hypersensitivity to pembrolizumab and/or enzalutamide and/or any of their excipients |
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| Has received prior ADT as neoadjuvant/adjuvant therapy for non-metastatic prostate cancer for >39 months in duration or within 9 months prior to randomization or with evidence of disease progression while receiving ADT |
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| Has had prior treatment with a next generation hormonal agent (eg, abiraterone, enzalutamide, apalutamide, darolutamide) |
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| Has received prior therapy with an anti-programmed cell death-1 (anti-PD-1), anti-programmed cell death-ligand 1 (anti-PD-L1), or anti PD-L2 agent or with an agent directed to another stimulatory or coinhibitory T-cell receptor |
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| Has received a live vaccine within 30 days prior to randomization |
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| Has a "superscan" bone scan |
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| Has had an allogenic tissue/solid organ transplant |
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| Is expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of study treatment |
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| Has received any prior pharmacotherapy, radiation therapy or surgery for metastatic prostate cancer with the following exceptions |
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| Up to 3 months of ADT or orchiectomy with or without concurrent first-generation antiandrogens, if patient was not treated with docetaxel |
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| May have 1 course of palliative radiation or surgical therapy to treat symptoms resulting from metastatic disease if it was administered at least 4 weeks prior to randomization |
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| For participants with low volume metastatic disease, may have 1 course of definitive radiotherapy if it was administered at least 4 weeks prior to randomization |
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| Up to 6 cycles of docetaxel therapy with final treatment administration completed within 2 months of randomization and no evidence of disease progression. In these participants up to 6 months of ADT permitted |
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