Hepatic Mitochondrial Function in Youth (MANGO)

  • STATUS
    Recruiting
  • End date
    Jun 30, 2023
  • participants needed
    25
  • sponsor
    University of Colorado, Denver
Updated on 4 October 2022
insulin
bariatric surgery

Summary

Assess the impact of bariatric surgery on hepatic energy metabolism and glucose and insulin dynamics in obese youth

Description

A metabolic study that will be performed prior to and 12 months following bariatric surgery. The study will include 31-phosphorus magnetic resonance spectroscopy to measure phosphate concentrations in the liver; a 4 hour mixed meal tolerance test, an intravenous arginine test, Abdominal Magnetic Resonance Imaging (MRI) for visceral and hepatic fat, Magnetic Resonance (MR) Elastography of the liver, indirect calorimetry, body composition assessment with Bodpod, serum metabolomics and hepatic tissue mitochondrial measures from the time of surgery only.

Details
Condition Hepatic Steatosis, Bariatric Surgery Candidate, Adolescent Obesity, Obesity
Clinical Study IdentifierNCT03587727
SponsorUniversity of Colorado, Denver
Last Modified on4 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Obese youth ages 13-20 years, scheduled for bariatric surgery at Children's Hospital Colorado
BMI 35-55 m2/kg
Maximal body circumference <200 cm

Exclusion Criteria

Use of medications known to affect insulin sensitivity: oral glucocorticoids within 10; days, atypical antipsychotics, immunosuppressant agents, HIV medications
Infectious hepatitis
Alcohol abuse
Mitochondrial disease
Type 2 diabetes
Medications that affect hepatic outcomes (e.g. PPAR-γ or PPAR-α, metformin)
Currently pregnant or breastfeeding women. Development of pregnancy during the study period will necessitate withdrawal from the study
Severe illness requiring hospitalization within 60 days
Diabetes, defined as Hemoglobin A1C > 6.4%
Anemia, defined as Hemoglobin < 10 mg/dL
Diagnosed major psychiatric or developmental disorder limiting informed consent
Implanted metal devices that are not compatible with MRI
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