Variations in the DIO2 and MCT10 Genes and Effect of Triiodothyronine Treatment

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    Birte Nygaard
Updated on 18 April 2021


Hypothesis: Variations in the deiodinase 2 gene and monocarboxylate transporter 10 gene is associated with improvement in quality of life after initiation of combination therapy with L-Thyroxine and Liothyronine in patients with persistent hypothyroid symptoms despite conventional L-thyroxine mono-therapy.

Purpose: To re-test this hypothesis in patients with continued perceived effect of Liothyronine treatment at least one year after initiation in a patient population more representing of daily clinical practice. The study will help determine whether testing of specific gene variations might predict longtime effect of combination therapy.

Condition Hypothyroidism, Thyroid disorder, Thyroid Disease, Thyroid Disorders, Thyroid Disease, Thyroid Disorders
Clinical Study IdentifierNCT03926585
SponsorBirte Nygaard
Last Modified on18 April 2021


Yes No Not Sure

Inclusion Criteria

Patients admitted to the department of endocrinology with the diagnose hypothyroidism because of persistent hypothyroid symptoms despite treatment with L-thyroxine mono-therapy and normal and stable TSH (for at least 6 months)
Started in combination therapy with L-thyroxine and Liothyronine in an approximately 17/1 ratio
Exclusion of an alternative explanation for persistent hypothyroid symptoms

Exclusion Criteria

Initiation of L-thyroxine treatment in patients with s-TSH below upper normal limit (with assay in current use, that is TSH < 4 mU/L)
Ongoing pregnancy
Age below 18 years or above 80 years
Patients who do not read and understand information material given
Patients who are not competent to give informed consent
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