Variations in the DIO2 and MCT10 Genes and Effect of Triiodothyronine Treatment

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    Birte Nygaard
Updated on 25 May 2022


Hypothesis: Variations in the deiodinase 2 gene and monocarboxylate transporter 10 gene is associated with improvement in quality of life after initiation of combination therapy with L-Thyroxine and Liothyronine in patients with persistent hypothyroid symptoms despite conventional L-thyroxine mono-therapy.

Purpose: To re-test this hypothesis in patients with continued perceived effect of Liothyronine treatment at least one year after initiation in a patient population more representing of daily clinical practice. The study will help determine whether testing of specific gene variations might predict longtime effect of combination therapy.

Condition Hypothyroidism
Clinical Study IdentifierNCT03926585
SponsorBirte Nygaard
Last Modified on25 May 2022

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