Safety and Efficacy of Capmatinib (INC280) Plus Pembrolizumab vs Pembrolizumab Alone in NSCLC With PD-L1 50%
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- STATUS
- Recruiting
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- End date
- Mar 28, 2023
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- participants needed
- 96
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- sponsor
- Novartis Pharmaceuticals
Summary
The purpose is to evaluate the efficacy and safety of the combination of capmatinib with pembrolizumab compared to pembrolizumab alone as first-line treatment for subjects with locally advanced or metastatic NSCLC who have PD-L1 expression 50% and have no EGFR mutation or ALK rearrangement. Capmatinib has demonstrated immunomodulatory activities when combined with an anti-PD1 antibody in preclinical tumor models irrespective of MET dysregulation. The combination of capmatinib with checkpoint inhibitors has been established to be tolerable and could provide additional clinical benefit to the subjects.
Details
| Condition | Non-Small Cell Lung Cancer, nsclc |
|---|---|
| Treatment | Pembrolizumab, capmatinib |
| Clinical Study Identifier | NCT04139317 |
| Sponsor | Novartis Pharmaceuticals |
| Last Modified on | 25 January 2021 |
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