French COVID Cohort (FrenchCOVID)

  • STATUS
    Recruiting
  • End date
    Aug 7, 2025
  • participants needed
    5000
  • sponsor
    Institut National de la Santé Et de la Recherche Médicale, France
Updated on 17 March 2022
antibiotics
fever
SARS
influenza
middle east respiratory syndrome
ebola virus disease
coronavirus infection

Summary

Infectious disease is the single biggest cause of death worldwide. New infectious agents, such as the SARS, MERS and other novel coronavirus, novel influenza viruses, viruses causing viral haemorrhagic fever (e.g. Ebola), and viruses that affect the central nervous system (CNS) such as TBEV & Nipah require investigation to understand pathogen biology and pathogenesis in the host. Even for known infections, resistance to antimicrobial therapies is widespread, and treatments to control potentially deleterious host responses are lacking.

In order to develop a mechanistic understanding of disease processes, such that risk factors for severe illness can be identified and treatments can be developed, it is necessary to understand pathogen characteristics associated with virulence, the replication dynamics and in-host evolution of the pathogen, the dynamics of the host response, the pharmacology of antimicrobial or host-directed therapies, the transmission dynamics, and factors underlying individual susceptibility.

The work proposed here may require sampling that will not immediately benefit the participants. It may also require analysis of the host genome, which may reveal other information about disease susceptibility or other aspects of health status.

Details
Condition Coronavirus Infections
Clinical Study IdentifierNCT04262921
SponsorInstitut National de la Santé Et de la Recherche Médicale, France
Last Modified on17 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Any patient admitted to a health care facility, with an infection confirmed by SARS-CoV-2 (virologically confirmed diagnosis by PCR)
Non inclusion criteria
Subject deprived of freedom, subject under a legal protective measure
Refusal by participant, parent or appropriate representative

Exclusion Criteria

Confirmed diagnosis of another pathogen than SARS-CoV-2 and no indication or likelihood of co-infection with SARS-CoV-2
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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