Ph II Study of Cabozantinib With Pembrolizumab in Metastatic Gastric and Gastroesophageal Adenocarcinoma

  • STATUS
    Recruiting
  • End date
    Jun 30, 2023
  • participants needed
    20
  • sponsor
    University of California, Irvine
Updated on 21 April 2022
tubal ligation
hysterectomy
fluorouracil
oophorectomy
metastasis
oxaliplatin
chemoradiotherapy
neutrophil count
cabozantinib
carboplatin
capecitabine
fluoropyrimidine
pembrolizumab
programmed cell death 1 ligand 1
adenocarcinoma
taxane
metastatic cancer

Summary

This is a phase 2 single-arm, open-label clinical trial determining efficacy of cabozantinib in combination with pembrolizumab in subjects with advanced gastric and gastroesophageal adenocarcinoma. These are subjects who have progressed, or not tolerated, at least one prior line of chemotherapy with a fluoropyrimidine and platinum agent.

Description

Treatment on study will be administered in 21 day cycles.

Details
Condition Gastric Adenocarcinoma, GastroEsophageal Cancer
Treatment Pembrolizumab, Cabozantinib
Clinical Study IdentifierNCT04164979
SponsorUniversity of California, Irvine
Last Modified on21 April 2022

Eligibility

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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