The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD
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- STATUS
- Recruiting
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- End date
- Mar 31, 2024
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- participants needed
- 230
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- sponsor
- Baylor University
Summary
MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which miR-210 regulates oxidative stress and provides evidence of potential therapeutic strategies.
Description
The investigators will randomize 180 PAD patients that undergoing a revascularization operation in two groups: (1) an endovascular procedure or (2) an open bypass procedure. They are also planning to recruit 50 non-PAD healthy control subjects.
The goal is to answer the main hypothesis that miR-210 gene expression is a master regulator of oxidative stress and is associated with mitochondrial dysfunction, oxidative metabolism, walking function and quality of life.
Details
| Condition | Peripheral Arterial Disease, Vascular Diseases, Peripheral, Arterial Occlusive Diseases, Atherosclerosis |
|---|---|
| Treatment | Control group, Revascularization operation |
| Clinical Study Identifier | NCT04089943 |
| Sponsor | Baylor University |
| Last Modified on | 16 March 2022 |
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