CMV-TCR-T Cells for CM Virus Infection After HSCT

  • participants needed
  • sponsor
    Hebei Yanda Ludaopei Hospital
Updated on 7 February 2023


This is a single cente, single arm, open-label, phase I study to evaluate the safety and effectiveness of CMV-TCR-T cell immunotherapy in treating CMV virus infection after HSCT.


CMV infection is a common virus infection of HSCT, and which is highly related with the failure of transplantation and survival time of transplant patients. To evaluate the safety and efficacy of allogenic CMV-TCR-T cell therapy in subjects with CMV infection, patients with CMV emias or deseases will be enrolled, and donor derived CMV-TCR-T(HLA-A*1101\0201\2402) cells will be intravenously infused with a escalated dose of 0.1-1×106 CMV-TCR-T cells. The CMV DNA copies and CMV-TCR-T cell proliferation will be monitored in the scheduled time (day 0, day 4, day 7, day 10, day 14, day 28).

Condition CMV Infection or Reactivation After Allogenic HSCT
Treatment CMV-TCR-T cells
Clinical Study IdentifierNCT04153279
SponsorHebei Yanda Ludaopei Hospital
Last Modified on7 February 2023

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