Last updated on July 2019

Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors


Brief description of study

This clinical trial studies cancer survivors to identify those who are at increased risk of developing late-occurring complications after undergoing treatment for childhood cancer. A patient's genes may affect the risk of developing complications, such as congestive heart failure, heart attack, stroke, and second cancer, years after undergoing cancer treatment. Genetic studies may help doctors identify survivors of childhood cancer who are more likely to develop late complications.

Detailed Study Description

PRIMARY OBJECTIVES:

I. To identify key adverse events developing in patients (cases) with a primary cancer diagnosed at age 21 or younger.

II. To characterize the key adverse events with respect to the nature of the primary malignancy (pathology, stage) and coded details of the therapeutic protocol.

III. To identify treatment-related and demographic risk factors through a direct comparison of the case-group and controls identified from the remaining patients with the same primary diagnosis.

IV. To compare the frequency of mutations or polymorphisms in specific candidate genes in cases and controls, using constitutional deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) from the cases and controls.

V. To explore the role and nature of gene-environment interaction in the development of key adverse events.

OUTLINE

DNA and RNA from peripheral blood or buccal sample of patients is analyzed for the presence of polymorphisms in candidate genes associated with an increased risk of late-occurring complications.

Clinical Study Identifier: NCT00082745

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Children's Hospital New Orleans

New Orleans, LA United States
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Kaiser Permanente-Oakland

Oakland, CA United States
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Saint Peter's University Hospital

New Brunswick, NJ United States
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Children's Hospital of Alabama

Birmingham, AL United States
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Yale University

New Haven, CT United States
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Norton Children's Hospital

Louisville, KY United States
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Bronson Methodist Hospital

Kalamazoo, MI United States
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Driscoll Children's Hospital

Corpus Christi, TX United States
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Fort Worth, TX United States
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Inova Fairfax Hospital

Falls Church, VA United States
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Arkansas Children's Hospital

Little Rock, AR United States
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C S Mott Children's Hospital

Ann Arbor, MI United States
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