Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy

  • STATUS
    Recruiting
  • End date
    Oct 30, 2026
  • participants needed
    40
  • sponsor
    Jessa Hospital
Updated on 26 February 2022
audiometry

Summary

In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well.

The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.

Details
Condition Hearing Loss, Sensorineural, Bilateral Vestibular Deficiency, DFNA9, Radiology
Treatment Audiometry, vestibular test 1, vestibular test 2, vestibular evoked myogenic potentials, vestibular evoked myogenic potentials, CT and MR imaging of temporal bone, p.P51S mutation
Clinical Study IdentifierNCT04070937
SponsorJessa Hospital
Last Modified on26 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain <0.6, measured by the video-HIT5 or scleral-coil technique and/or
reduced caloric response6 (sum of bither- mal max. peak SPV on each side <6/sec7) and/or
reduced horizontal angular VOR gain <0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50 /sec) and a phase lead >68 degrees (time constant <5 sec)
must be 18 or older

Exclusion Criteria

< 18 y
does not meet Barany criteria for BV
contraindication for CT and MR imaging
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