A First-in-human, Two-part Clinical Study to Assess the Safety, Tolerability and Activity of IV Doses of ICT01 as Monotherapy and in Combination With a Checkpoint Inhibitor, in Patients With Advanced-stage, Relapsed/Refractory Cancer (EVICTION)

  • STATUS
    Recruiting
  • End date
    Jun 28, 2024
  • participants needed
    150
  • sponsor
    ImCheck Therapeutics
Updated on 28 October 2022
cancer
myeloid leukemia
hematologic malignancy
lymphoma
monoclonal antibodies
measurable disease
leukemia
advanced cancer
follicular lymphoma
solid tumour
solid tumor
antibody therapy
diffuse large cell lymphoma

Summary

Part 1 will be a dose escalation study of IV ICT01 (a monoclonal antibody targeting BTN3A) as monotherapy in patients with advanced solid or hematologic tumors, followed by a cohort examining the combination of ICT01 plus pembrolizumab (Keytruda). Part 2 will be a cohort expansion into 2 solid tumor indications and one hematologic malignancy for ICT01 monotherapy, and 3 solid tumor indications for the combination of ICT01 plus pembrolizumab.

Details
Condition Solid Tumor, Adult, Hematopoietic/Lymphoid Cancer
Treatment IV ICT01
Clinical Study IdentifierNCT04243499
SponsorImCheck Therapeutics
Last Modified on28 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Voluntarily signed informed consent form
Relapsed/refractory patients with histologically or cytologically confirmed diagnosis of advanced-stage or recurrent cancer, including
Group A: bladder, breast, colon, gastric, melanoma, ovarian, prostate and PDAC
Group
hematologic malignancies including acute myeloid leukemia, acute lymphocytic leukemia, Diffuse large B cell lymphoma and follicular lymphoma Group C: melanoma, cervical, bladder, gastric, head and neck SCC, and lymphoma (according to the approved package labeling of the ICI) Part 2, Group D: Ovarian cancer (2L/3L) with baseline g9d2 T cells > 20K Part 2, Group E: metastatic castrate resistant prostate cancer (2L/3L) with baseline g9d2 T cells > 20K Part 2, Group G: checkpoint-refractory metastatic melanoma with g9d2 T cells >5K Part 2, Group H: chemotx-refractory or Pt-ineligible urotherlial cancer (bladder) with g9d2 T cells >5K Part 2, Group I: checkpoint-refractory, metastatic HNSCC with g9d2 T cells >5K
Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1
Life expectancy > 3 months as assessed by the Investigator
At least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST)/ Response Evaluation Criteria in Lymphoma (RECIL) or >5% marrow blasts

Exclusion Criteria

Any malignancy of Vγ9Vδ2 T cell origin
Any anti-tumor-directed drug therapy within 28 days or 5 times the elimination half-life (whichever is shorter) before study treatment (does not apply to patients receiving ICI for the combination arm)
Ongoing immune-related adverse events (irAEs) and/or AEs ≥grade 2 not resolved from previous therapies except vitiligo, stable neuropathy up to grade 2, hair loss, and stable endocrinopathies with replacement hormone therapy
Treatment with investigational drug(s) within 28 days before study treatment
Systemic steroids at a daily dose of > 10 mg of prednisone, > 2 mg of dexamethasone or equivalent, for the last 28 days and need for ongoing treatment
Patients with rapidly progressing disease defined as advanced/metastatic, symptomatic, visceral spread, with a risk of life-threatening complications in the short term (e.g., during Screening Period/ treatment washout) that includes patients with massive uncontrolled effusions pleural, pericardial, peritoneal, pulmonary lymphangitis, and over 50% liver involvement
Within 4 weeks of major surgery
Documented history of active autoimmune disorders requiring systemic immunosuppressive therapy within the last 12 months
Primary or secondary immune deficiency
Active and uncontrolled infections requiring intravenous antibiotic or antiviral treatment
Clear my responses

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