Cancer Therapy Effects on the Heart (CTEH)
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- STATUS
- Recruiting
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- End date
- Sep 30, 2029
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- participants needed
- 60
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- sponsor
- Hari Narayan
Summary
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.
Description
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.
Cardiac remodeling, function, and tissue characteristics will be examined using cardiac MRI data in combination with standard cardiac assessments (by echocardiography, electrocardiograms, and cardiac MRI) to assess the cardiotoxic effects of cancer therapy. Analyses will be performed in a cohort of adolescents and young adults with a history of childhood cancer.
Details
| Condition | Cardiotoxicity, Pediatric Cancer, Heart Failure |
|---|---|
| Treatment | Echocardiography, Electrocardiogram, Cardiac magnetic resonance imaging (MRI) |
| Clinical Study Identifier | NCT04262830 |
| Sponsor | Hari Narayan |
| Last Modified on | 26 February 2022 |
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