Cancer Therapy Effects on the Heart (CTEH)

  • STATUS
    Recruiting
  • End date
    Sep 30, 2029
  • participants needed
    60
  • sponsor
    Hari Narayan
Updated on 26 February 2022
electrocardiogram
cancer
heart failure
MRI
diagnostic tests
daunorubicin
doxorubicin
anthracyclines
metastasis
cancer treatment
cardiac mri
childhood cancer

Summary

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.

Description

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.

Cardiac remodeling, function, and tissue characteristics will be examined using cardiac MRI data in combination with standard cardiac assessments (by echocardiography, electrocardiograms, and cardiac MRI) to assess the cardiotoxic effects of cancer therapy. Analyses will be performed in a cohort of adolescents and young adults with a history of childhood cancer.

Details
Condition Cardiotoxicity, Pediatric Cancer, Heart Failure
Treatment Echocardiography, Electrocardiogram, Cardiac magnetic resonance imaging (MRI)
Clinical Study IdentifierNCT04262830
SponsorHari Narayan
Last Modified on26 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

English and Spanish speaking male and female subjects, ages 13-39 years old
Diagnosis of cancer at age <22 years
Previously treated with anthracyline therapy for cancer, with diagnosis at least two years prior

Exclusion Criteria

Patients who have a contraindication to cardiac MRI, including the presence of non-MRI compatible metallic implants
Medical, psychiatric, and/or social disorder that would prevent successful completion of planned study testing or would preclude the subject from undergoing the cardiac MRI without anesthesia
Patients with a history of congenital heart disease (more significant than a history of patent foramen ovale or patent ductus arteriosus)
Patients with orthodontic braces or metallic implants in the thorax or abdomen/lumbar spine, even if MRI-compatible, will be excluded as these may cause artifacts and limit image quality
Pregnancy
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