Thrice-weekly Versus Thrice-daily Oral Ferrous Fumarate Treatment in Adult Patients With Iron Deficiency Anemia

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  • participants needed
  • sponsor
    Prince of Songkla University
Updated on 25 January 2021
ferrous fumarate


Iron deficiency anemia is a global health problem and the most common cause of anemia worldwide. Patients with iron deficiency and Iron deficiency anemia can present with a multitude of symptoms including fatigue, dyspnea on exertion, dysphagia, pallor, palpitations, headaches, tinnitus, taste disturbance and pica. Oral iron supplementation is associated with increasing hemoglobin in multiple studies in women, pregnant women and elderly patients. However, the optimal dose and frequency of oral iron supplementation for treatment remains unclear. The current proposed study attempts to address this gap in the literature.

Condition Iron deficiency anemia, Iron Deficiency, anemia, iron deficiency
Treatment Ferrous fumarate
Clinical Study IdentifierNCT04130828
SponsorPrince of Songkla University
Last Modified on25 January 2021


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Inclusion Criteria

Age 18-60 years
Outpatients with iron deficiency anemia defined as hemoglobin less than 12 g/dL in women or 13 g/dL in men; AND ferritin less than 30 ng/mL

Exclusion Criteria

Allergy to iron
Allergy to albendazole
Currently pregnancy
Currently breastfeeding
Known history of inflammatory bowel disease, celiac disease, inherited bleeding disorder, solid cancer, hematologic cancer or thalassemia
Renal impairment or glomerular filtration rate less than 30 ml/min/1.73m2
Hepatic impairment or Child Pugh score more than 7
Active bleeding define hemoglobin decrease more than 2 g/dL
Multivitamin and mineral supplement (35 mg or more of elemental iron per day) in 2 weeks prior to randomization
Subject withdrawal criteria
Intolerance to drugs
Active bleeding define hemoglobin decrease more than 2 g/dL
Major surgery
Blood transfusion
Loss follow-up more than 2 weeks
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