Xcellerated T CellsTM for Non-Hodgkin s Lymphoma (NHL) Patients

  • STATUS
    Recruiting
  • participants needed
    40
  • sponsor
    Xcyte Therapies
Updated on 7 November 2020
platelet count
chronic lymphocytic leukemia
hodgkin's disease
rituximab
flow cytometry
measurable disease
neutrophil count
blood transfusion
follicular lymphoma
b-cell lymphoma
mantle cell lymphoma
marginal zone lymphoma
indolent lymphoma

Summary

This is a Phase II single arm study of a novel T cell immunotherapy in patients with indolent non-Hodgkin’s lymphoma (NHL). Eligible patients will have relapsed or refractory disease after receiving at least one and no more than four prior regimens. Patients will receive Xcellerated T CellsTM, an ex vivo activated and expanded autologous T cell product, in an attempt to enhance immune responses with anti-tumor activity. The primary endpoint of the study is to evaluate the efficacy of Xcellerated T Cells in patients with indolent NHL. Secondary endpoints are to evaluate the safety of the therapy in this patient population, and to evaluate changes in the number and phenotype of T- and B-lymphocytes, as well as changes in the T cell receptor repertoire, hemoglobin levels, platelet counts and quantitative immunoglobulin levels. In a subset of patients, fine-needle aspirates of malignant lymph nodes will be performed to assess changes in the lymphocyte composition and phenotype. Bone marrow aspirates will be similarly evaluated. Finally, anti-tumor immune responses will be evaluated in patients amenable to biopsy of enlarged lymph nodes.

Details
Condition Lymphoma
Treatment Xcellerated T Cells
Clinical Study IdentifierNCT00081783
SponsorXcyte Therapies
Last Modified on7 November 2020

Eligibility

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