Last updated on June 2005

Xcellerated T CellsTM for Non-Hodgkin s Lymphoma (NHL) Patients


Brief description of study

This is a Phase II single arm study of a novel T cell immunotherapy in patients with indolent non-Hodgkin’s lymphoma (NHL). Eligible patients will have relapsed or refractory disease after receiving at least one and no more than four prior regimens. Patients will receive Xcellerated T CellsTM, an ex vivo activated and expanded autologous T cell product, in an attempt to enhance immune responses with anti-tumor activity. The primary endpoint of the study is to evaluate the efficacy of Xcellerated T Cells in patients with indolent NHL. Secondary endpoints are to evaluate the safety of the therapy in this patient population, and to evaluate changes in the number and phenotype of T- and B-lymphocytes, as well as changes in the T cell receptor repertoire, hemoglobin levels, platelet counts and quantitative immunoglobulin levels. In a subset of patients, fine-needle aspirates of malignant lymph nodes will be performed to assess changes in the lymphocyte composition and phenotype. Bone marrow aspirates will be similarly evaluated. Finally, anti-tumor immune responses will be evaluated in patients amenable to biopsy of enlarged lymph nodes.

Clinical Study Identifier: NCT00081783

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Virginia Mason

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Sharp Memorial Hospital

San Diego, CA United States
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Atlanta Cancer Care

Roswell, GA United States
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Greenbrae, CA United States
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Cancer Institute of New Jersey

New Brunswick, NJ United States
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St. Louis, MO United States
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Baltimore, MD United States
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MD Anderson Cancer Center

Houston, TX United States
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Swedish Cancer Institute

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Columbus, OH United States
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Cancer Centers of the Carolinas

Greenville, SC United States
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