The Purpose of This Study is to Evaluate the Efficacy and Safety of Sintilimab in Combination With Xelox as Neoadjuvant Therapy for Patients With Resectable Locally Advanced Gastric or Gastroesophageal Adenocarcinoma.

  • STATUS
    Recruiting
  • participants needed
    36
  • sponsor
    First Affiliated Hospital of Zhejiang University
Updated on 21 May 2022
measurable disease
oxaliplatin
gastric adenocarcinoma
capecitabine
adjuvant therapy
cancer chemotherapy
adenocarcinoma
xelox regimen

Summary

Sintilimab in Combination With Capecitabine and Oxaliplatin (XELOX) as Neoadjuvant Therapy in patients With Resectable Locally Advanced Gastric Cancer

Description

This prospective, multicenter, single-armed, phase II study will evaluate efficacy and safety of Sintilimab in combination with Xelox (Oxaliplatin 130mg/m2 iv d1 Q3w and Capecitabine 1000mg/m2 po Bid d1-14 Q3W) as neoadjuvant therapy in patients with resectable locally advanced gastric or gastroesophageal adenocarcinoma(G/GEJ AC). Newly diagnosed, treatment nave patients with resectable locally advanced gastric or G/GEJ AC will be eligible to receive up to 3 cycles of sintilimab plus Xelox regimen as neoadjuvant therapy. Following radical gastrectomy will be performed within one to four weeks since last dosing for patients with resectable cancer after radiological evaluation.

Details
Condition Gastric Cancer
Treatment Capecitabine, Oxaliplatin, Sintilimab
Clinical Study IdentifierNCT04065282
SponsorFirst Affiliated Hospital of Zhejiang University
Last Modified on21 May 2022

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