The Exercise And Colorectal Cancer Treatment Trial (EXACT)
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- STATUS
- Recruiting
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- End date
- Apr 30, 2024
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- participants needed
- 60
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- sponsor
- Pennington Biomedical Research Center
Summary
This study will examine the biologic processes through which exercise may prevent disease recurrence in patients who have completed treatment for colorectal cancer.
Description
This randomized trial will examine the biological effects of 12-weeks of moderate-intensity aerobic exercise versus wait-list control in 60 subjects who have completed standard medical therapy for colorectal cancer. The primary objective is to determine if aerobic exercise can reduce systemic inflammation, quantified using plasma concentrations of high-sensitivity C-reactive protein, interleukin-6, and soluble tumor necrosis factor-alpha receptor two. The secondary objectives are to determine if exercise can reduce: 1) insulin resistance quantified using an oral glucose tolerance test, and; 2) circulating tumor cells quantified using a microfluidic antibody-mediated capture platform. The exploratory objective is to determine if exercise can improve mitochondrial respiration rates and fatty acid oxidation.
Details
| Condition | Colon Cancer, Rectal Cancer |
|---|---|
| Treatment | Wait-list control, Moderate-Intensity Aerobic Exercise |
| Clinical Study Identifier | NCT03975491 |
| Sponsor | Pennington Biomedical Research Center |
| Last Modified on | 24 March 2022 |
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