Epigenetic Biomarker for Advanced Osteosarcoma Using Famitinib and Camrelizumab

  • STATUS
    Recruiting
  • participants needed
    40
  • sponsor
    Peking University People's Hospital
Updated on 29 January 2022

Summary

hMe-Seal is a low-input whole-genome cell-free 5hmC sequencing method based on selective chemical labeling. It uses -glucosyltransferase (GT) to selectively label 5hmC with a biotin via an azide-modified glucose for pull-down of 5hmC-containing DNA fragments for sequencing. After selectively constructing 5hmC library, highthroughput-sequencing will be performed on an Illumina Nextseq-500 instrument. By ways of Rawdata processing, differential loci between Osteosarcoma group and control group will be detected to indentify specific epigenetic biomarkers of Osteosarcoma. From our previous trials, we identify geno sequencing related to beta-catenin pathways might have some relationship with osteosaroma primary or secondary drug resistance. Thus in this trial we try to further explore the drug resistance mechanism for advaced osteosarcoma second resistance to the combination therapy of Famitinib and Camrelizumab.

Details
Condition Drug Resistance to Famitinib and Camrelizumab, Biomarkers for Efficacy and Toxicity
Treatment 5hmc testing
Clinical Study IdentifierNCT03919539
SponsorPeking University People's Hospital
Last Modified on29 January 2022

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