The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations

  • participants needed
  • sponsor
    Marshall University
Updated on 2 December 2022
ct scan
antibiotic therapy
ruptured appendicitis
acute perforated appendicitis


Patients admitted at Marshall Health - Cabell Huntington Hospital with the diagnosis of acute perforated appendicitis or appendicular abscess larger than 3cm will be admitted and treated with percutaneous drainage and the IV antibiotics for 3 days. If the patient becomes afebrile and has a normal WBC, the patient will stay in the hospital for a single day with oral antibiotics and then will be discharged to continue oral antibiotics for seven more days. If the patient is febrile or has elevated WBC either after the 3 days of IV antibiotics or the single day of oral antibiotics, the patient will complete a course of IV antibiotics for a total of seven days. If still febrile, the patient will undergo further assessment.

A follow up will be conducted ~10 days after discharge from the hospital to determine if the patient is still symptomatic or asymptomatic. Asymptomatic patients will be followed up every month for 3 months, while symptomatic patients will be treated as needed. After 12 weeks, subjects will be randomized to interval appendectomy vs observation. Follow-ups will occur every 3 months for 12 months, when the study will be concluded.

Condition Perforated Appendicitis
Treatment Observation, appendectomy
Clinical Study IdentifierNCT04253899
SponsorMarshall University
Last Modified on2 December 2022

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