Theta Burst Stimulation in Young Adults With Depression

    Not Recruiting
  • participants needed
  • sponsor
    Erika Forbes
Updated on 19 August 2022
depressive disorder
depressed mood
transcranial magnetic stimulation
major depressive disorder
dysthymic disorder


For the proposed 2-year study, the investigators will conduct a within-subject, counterbalanced investigation using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) to examine the acute effects of theta-burst stimulation (TBS) on function in dorsomedial prefrontal cortex (dmPFC) in 35 young adults with depression (18-25 years, 50% female).


Each participant will undergo 3 sessions of TMS, one each of continuous and intermittent TBS--with the goal of decreasing or increasing dmPFC responding, respectively--and one of sham TBS. Session order will be counterbalanced, with a double-blind approach to condition. Brain function, behavior, and mood will be assessed before and after each TBS session. Broadly, the investigators predict that inhibitory TBS to the dmPFC will enhance neural, behavioral, and subjective aspects of reward function by reducing dmPFC function and dmPFC connectivity with the ventral striatum (VS).

Condition Depression
Treatment intermittent theta burst stimulation, continuous theta burst stimulation, sham theta burst stimulation
Clinical Study IdentifierNCT03737032
SponsorErika Forbes
Last Modified on19 August 2022

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