LITT and Pembrolizumab in Recurrent Brain Metastasis (TORCH)

  • STATUS
    Recruiting
  • End date
    Oct 19, 2025
  • participants needed
    16
  • sponsor
    University of Florida
Updated on 4 October 2022
vasectomy
cancer
tubal ligation
hysterectomy
lymphoma
carcinoma
direct bilirubin
squamous cell carcinoma
lung cancer
oophorectomy
dexamethasone
probe
metastasis
esophageal cancer
pembrolizumab
brain metastases
follicle stimulating hormone
gastric cancer
conjugated bilirubin
b-cell lymphoma
msi-h
contrast-enhanced mri
hormone replacement
esophagus cancer
serum total bilirubin
lung carcinoma
urothelial carcinoma

Summary

This is an open-label, historically controlled pilot study investigating the immune effect of Laser Interstitial ThermotHerapy (LITT)+ pembrolizumab in adult patients with a primary cancer approved by the FDA for treatment with an immune-checkpoint inhibitor who have recurrent brain metastasis after prior stereotactic radiosurgery (SRS).

Description

Adult patients with a primary cancer approved by the FDA for treatment with an immune-checkpoint inhibitor who have recurrent brain metastasis that have failed stereotactic radiosurgery treatment will be screened. They will sign consent and complete screening procedures. Each patient will be scheduled to undergo biopsy and LITT treatment. Within two weeks of surgery, patients will begin receiving pembrolizumab every three weeks. Pembrolizumab infusions will continue until brain met recurrence per RANO for Brain Mets or up to two years, whichever comes first. Blood samples will be collected for immune monitoring. Tumor tissue will be collected for immune and genomic studies. Approximately 21 patients will be enrolled to accrue 15 evaluable subjects. Patients will be followed for survival data for one year or until death, whichever comes first.

Details
Condition Melanoma, Non-small Cell Lung Carcinoma (NSCLC), Renal Cell Carcinoma (RCC), Small-cell Lung Cancer, Head and Neck Squamous Cell Cancer, Classical Hodgkin Lymphoma, Primary Mediastinal Large B-Cell Lymphoma, Urothelial Carcinoma, Microsatellite Instability-High Cancer, Gastric Cancer, Esophageal Cancer, Cervical Cancer, Hepatocellular Carcinoma, Merkel Cell Carcinoma, Brain Metastases, Adult
Treatment LITT + Pembrolizumab
Clinical Study IdentifierNCT04187872
SponsorUniversity of Florida
Last Modified on4 October 2022

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