Trial Comparing 2 Diagnostic Strategies for Preoperative Localization of Parathyroid Adenoma in Primary Hyperparathyroidism:TEMP / CT With Tc99m-sestaMIBI or PET / CT With F18-choline in First Intention

  • STATUS
    Recruiting
  • End date
    Mar 10, 2022
  • participants needed
    58
  • sponsor
    Centre Francois Baclesse
Updated on 10 May 2021
calcium
adenoma
positron emission tomography
sestamibi
scintigraphy
hyperparathyroidism
parathyroid disease
parathyroid hormones
primary hyperparathyroidism
parathyroid adenoma

Summary

The investigators hypothesize that positron emission tomography with fluorocholline (F18-choline PET) will reduce the proportion of unnecessary invasive surgery decisions and that the higher cost of positron emission tomography versus MIBI scintigraphy (Tc99m-sestaMIBI ) will be offset by lower cost in terms of type. surgery performed wisely and complications.

Details
Condition Hyperparathyroidism, Parathyroid Adenoma, PARATHYROID DISORDER, head and neck cancer, Hyperparathyroidism (Pediatric), Parathyroid Disorders, Parathyroid Disease, Parathyroid Cancer, F18-choline, F18-choline, F18-choline, F18-choline, F18-choline, F18-choline, F18-choline, F18-choline
Treatment MIBI scintigraphy, F18-choline PET
Clinical Study IdentifierNCT04040946
SponsorCentre Francois Baclesse
Last Modified on10 May 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient 18 years old
Patient presenting with primary hyperparathyroidism and for whom an excisional surgery is planned
For women of childbearing age, negative pregnancy test at Baseline
Biological assessment confirming the diagnosis of primary hyperparathyroidism (high serum PTH and calcium concentrations)
Affiliation to a social security scheme
Patient having signed his written consent

Exclusion Criteria

Patient deprived of liberty, under tutorship or curatorship
Hypersensitivity to TECNESCAN SESTAMIBI
Any associated medical or psychological condition that could compromise the patient's ability to participate in the study
Pregnant or lactating woman
History of parathyroid surgery
Patient with multiple endocrine neoplasia 1 (NEM1)
Known hypersensitivity to fluorocholine or to any of the excipients (sodium chloride, water for injections)
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