This is a Phase I/II study using the combination of twice weekly ixazomib plus pomalidomide
and dexamethasone in relapsed and or refractory multiple myeloma (RRMM) patients.
This is a Phase I/II clinical trial. A Phase I clinical trial tests the safety of an
investigational drug and tries to define the appropriate dose of the investigational drug to
use for further studies. "Investigational" means that the drug is being studied.
The FDA has approved both pomalidomide and ixazomib individually for the treatment of
multiple myeloma. Dexamethasone, also FDA approved, is a type of steroid and is usually
combined with other chemotherapy for the treatment of blood cancers, such as myeloma and
Ixazomib targets a part of cells called proteasomes. It works by slowing down or
blocking proteasomes from doing their job of digesting proteins. In myeloma cells, there
is a greater need for proteasomes to digest proteins; the buildup of excess proteins
causes cell death.
Pomalidomide has also been shown to cause tumor cell deaths. Dexamethasone can stop
white blood cells from traveling to areas myeloma cells are causing damage. When
combined with myeloma drugs, it sometimes makes those drugs work better.
In this research study, the investigators are:
Testing the safety of ixazomib when given with pomalidomide and dexamethasone
Pomalidomide and ixazomib are given individually for the treatment of multiple myeloma.
Dexamethasone is also given for multiple myeloma
Ixazomib when combined with pomalidomide and dexamethasone may help control the disease
Ixazomib is FDA approved to treat multiple myeloma
The investigators are looking for the highest dose of ixazomib that can be given safely
in combination with pomalidomide and dexamethasone
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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