The Impact of Phosphate Metabolism on Healthy Aging
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- STATUS
- Recruiting
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- End date
- Nov 30, 2022
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- participants needed
- 30
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- sponsor
- Yale University
Summary
Determine the association between duration and dose of chronic conventional therapy with Pi and renal (nephrocalcinosis/nephrolithiasis), vascular (endothelial function), and cardiovascular function (echo- cardiography) in patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH) and patients with X-linked hypophosphatemia (XLH).
Description
The central hypothesis of this proposal is that patients with X-linked hypophosphatemia (XLH), when matched for duration and dose of phosphate (Pi) therapy to patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH), will evidence greater cardiovascular and vascular debility than patients with HHRH. The overall objectives of this project are to utilize our existing longitudinal databases for individuals with XLH and HHRH through an interdisciplinary collaboration between pediatric and adult endocrinology to: i) quantify the impact of exposure to Pi therapy across the lifespan on cardiovascular and renal complications, which are key aging endpoints, ii) determine the acute response to Pi loading in XLH and HHRH by studying the changes in surrogate markers of cardiovascular and renal function.
Details
| Condition | Hypophosphatemia, Rickets, Hypercalciuria, XLH, HHRH |
|---|---|
| Treatment | phosphate, phosphate |
| Clinical Study Identifier | NCT03771105 |
| Sponsor | Yale University |
| Last Modified on | 23 May 2022 |
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