The "PC-LIGHT" Study

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Northwestern University
Updated on 22 March 2022
external beam radiation therapy
cancer-related fatigue


Fatigue due to cancer and its treatment (for example, radiation therapy) can interfere with quality of life and can linger long after treatment has ended, yet research examining preventative approaches has produced limited clinical benefit. The proposed study will provide information about systematic light exposure for the prevention of fatigue in prostate cancer patients undergoing radiation therapy and will investigate how it works. This study would facilitate the development of this potential preventative treatment, giving health care providers and cancer survivors a much-needed tool to help with cancer-related fatigue.

Condition Prostate Cancer, Sleep, Depression, Fatigue, Quality of Life
Treatment Intervention systematic light exposure, Comparison systematic light exposure
Clinical Study IdentifierNCT03419585
SponsorNorthwestern University
Last Modified on22 March 2022


Yes No Not Sure

Inclusion Criteria

Have been diagnosed with clinical localized prostate cancer
Are about to begin external beam radiation therapy (RT) for prostate cancer
Are 18 years of age or older
Are able to speak or read English
Have internet access

Exclusion Criteria

History of light therapy use (e.g. systematic light exposure)
Active infection
History of chronic fatigue disorders
Confounding underlying medical illnesses such as significant pre-existing anemia (Hb<10 gm/dl)
Diagnosed or suspected psychiatric or medical condition that might contribute to fatigue (other than those caused by the cancer or its treatment)
Hypothyroidism or documented history of hypothyroidism on thyroid replacement hormone within <3 months of initiating RT
History of bipolar disorder or mania
History of seasonal affective disorder
Diagnosed sleep apnea, restless legs, or other sleep disorders (not including insomnia) known to affect fatigue
Use of photosensitizing medication
Plans to travel across more than 2 time zones during the study
Shift worker
Adults unable to consent, individuals who are not yet adults, pregnant women, and prisoners will be excluded from the study
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What happens next?
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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