The Impact of Bariatric Surgery on Adipocyte Metabolism

  • End date
    Dec 23, 2025
  • participants needed
  • sponsor
    University of Chicago
Updated on 23 March 2022
bariatric surgery
Accepts healthy volunteers


The purpose of this study is to understand how daily rhythms of behavior affect the expression of genes in fat cells, and how these daily cycles affect the way fat cells respond to insulin (a hormone that controls blood sugar levels) before and after bariatric surgery.


Bariatric surgery as a means of weight loss has become increasingly popular over the last 10-15 years. In addition to promoting weight loss, bariatric surgery has become increasingly recognized for use in the management of diabetes. Recent studies have indicated that bariatric surgery can result in a marked improvement in insulin sensitivity before long term weight loss is attained. The goal of this project is to delineate the changes in the insulin responsiveness of subcutaneous adipocytes obtained by needle biopsy 2 weeks prior to surgery vs. 12 weeks after bariatric surgery, which could account for improvements in overall insulin sensitivity seen before any long-term sustained weight loss has occurred. The investigators will also examine gene expression in adipocytes (fat cells).

Condition Metabolic Syndrome, Obesity
Treatment Circadian Clock Alignment, Circadian Clock Control
Clinical Study IdentifierNCT04242524
SponsorUniversity of Chicago
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

-55 years old
BMI less than 30 kg/m2
Signed informed consent

Exclusion Criteria

Diagnosed with a systemic illnesses, including heart, renal, liver, or malignant disease
Uncontrolled hypertension (blood pressure greater than 140 mmHg systolic and 90 mmHg diastolic without medication)
use of beta blockers
hemoglobin less than 11.5g/dL
known allergy to lidocaine
Subjects will not have undergone surgery, donated a unit of blood, or participated in another clinical study within the last 4 weeks prior to consent
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