• days left to enroll
  • participants needed
  • sponsor
    Federation of Breast Diseases Societies
Updated on 25 February 2022
Accepts healthy volunteers


Omitting axilary lymph node dissection (ALND) following SLNB with residual cancer in patients with locally advanced disease after neoadjuvan chemotherapy (NAC) is still controversial. In this study, the investigators evaluated factors affecting local recurrence and outcome in patients with locally advanced breast cancer (LABC), who underwent sentinel lymph node (SLN) with or without ALND after NAC.


All patients with clinically positive axilla will undergo neoadjuvant chemotherapy. Axillary fine needle aspiration biopsy or Trucut biopsy is mandatory.

All patients with clinically node negativity (physical exam, USG, and/or MRI, PET-CT) after Neoadjuvant Chemotherapy (NAC) will be considered for SLNB with any technique (blue dye alone, radionuclide alone or both combined) and any breast surgery (mastectomy or breast conservation). PET-CT and MRI are not mandatory. PE and USG and/or MRI are preferred. At least, 2 sentinel lymph nodes will be obtained. Intraoperative evaluation of SLNs is recommended.

All patients with clinally-negative axilla and underwent SLNB will be included into the

  1. SLNB (-) & RT
  2. SLNB (+) & RT
  3. SLNB (+) & ALND & RT Radiotherapy details will be announced as supplementary

Condition Sentinel Lymph Node
Clinical Study IdentifierNCT04250129
SponsorFederation of Breast Diseases Societies
Last Modified on25 February 2022


Yes No Not Sure

Inclusion Criteria

T0-4, N1-3, M0

Exclusion Criteria

Inflammatory breast cancer, pregnant patients Patients with metastatic disease
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