Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors

  • STATUS
    Recruiting
  • End date
    Mar 14, 2025
  • participants needed
    56
  • sponsor
    University of Utah
Updated on 5 October 2021
platelet count
myelofibrosis
granulocyte colony stimulating factor
ruxolitinib
growth factor
erythropoietin
hemolysis
colony stimulating factor
gm-csf
neutrophil count
g-csf
platelet transfusion
eltrombopag
platelet transfusions
romiplostim
essential thrombocythemia
thrombocytosis
polycythemia

Summary

This is a phase II, open label, prospective, single-arm study evaluating the efficacy and safety of selinexor in patients with PMF or secondary MF (PPV-MF or PET-MF) who are refractory or intolerant to ruxolitinib and/or any other experimental JAK1/2 inhibitors.

Details
Condition Myelosclerosis with myeloid metaplasia, Post-PV MF, Post Essential Thrombocythemia Myelofibrosis, Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post Polycythemia Vera Myelofibrosis
Treatment Selinexor
Clinical Study IdentifierNCT03627403
SponsorUniversity of Utah
Last Modified on5 October 2021

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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