The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery

  • STATUS
    Recruiting
  • End date
    Dec 24, 2021
  • participants needed
    414
  • sponsor
    Yonsei University
Updated on 24 January 2021
diabetes
hypertension
heart failure
heart disease
infarct
acute renal failure
heart surgery
cerebral infarction

Summary

Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and cerebral infarction. Postoperative acute kidney injury after heart surgery is one of the major complications with incidence with 40~50%, however, there has been no preventive method or treatment yet. Recently, several studies have been published that have shown a correlation between sleep-disordered breathing and renal impairment. In general, sleep-disordered breathing can be regulated easily with continues positive expiratory pressure, which means that early diagnosis and treatment of sleep-disordered breathing might help to reduce the incidence of postoperative acute kidney injury and improve patients' prognosis.

In this study, the investigators investigate the impact of sleep-disordered breathing (diagnosed by oxygen desaturation index 5) on the incidence of postoperative acute kidney injury in patients undergoing valvular heart surgery.

Details
Condition Heart disease, VALVULAR HEART DISEASE, Heart Valve Disease, Cardiac Disease
Clinical Study IdentifierNCT04080219
SponsorYonsei University
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patient aged more than 20 years
Patients undergoing valvular heart surgery

Exclusion Criteria

Emergency
Simultaneous surgery with coronary artery bypass graft
Previous history of cerebrovascular accident
Previous history of sleep disordered breathing (diagnosis & treatment)
Previous history of tracheostomy
Previous history of surgical treatment of airway (ex: nasopharyngeal cancer)
Preoperative oxygen supplement therapy
Patients who have participated in other clinical studies that may affect prognosis
Patients who cannot read and agree to informed consent (ex: foreigners, cognitive dysfunction)
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