The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery

  • End date
    Dec 24, 2021
  • participants needed
  • sponsor
    Yonsei University
Updated on 24 January 2021
heart failure
heart disease
acute renal failure
heart surgery
cerebral infarction


Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and cerebral infarction. Postoperative acute kidney injury after heart surgery is one of the major complications with incidence with 40~50%, however, there has been no preventive method or treatment yet. Recently, several studies have been published that have shown a correlation between sleep-disordered breathing and renal impairment. In general, sleep-disordered breathing can be regulated easily with continues positive expiratory pressure, which means that early diagnosis and treatment of sleep-disordered breathing might help to reduce the incidence of postoperative acute kidney injury and improve patients' prognosis.

In this study, the investigators investigate the impact of sleep-disordered breathing (diagnosed by oxygen desaturation index 5) on the incidence of postoperative acute kidney injury in patients undergoing valvular heart surgery.

Condition Heart disease, VALVULAR HEART DISEASE, Heart Valve Disease, Cardiac Disease
Clinical Study IdentifierNCT04080219
SponsorYonsei University
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

Adult patient aged more than 20 years
Patients undergoing valvular heart surgery

Exclusion Criteria

Simultaneous surgery with coronary artery bypass graft
Previous history of cerebrovascular accident
Previous history of sleep disordered breathing (diagnosis & treatment)
Previous history of tracheostomy
Previous history of surgical treatment of airway (ex: nasopharyngeal cancer)
Preoperative oxygen supplement therapy
Patients who have participated in other clinical studies that may affect prognosis
Patients who cannot read and agree to informed consent (ex: foreigners, cognitive dysfunction)
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Phone Email

Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note