Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia

    Not Recruiting
  • End date
    Oct 15, 2022
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 18 April 2022
intestinal metaplasia
volumetric laser endomicroscopy


Researchers are trying to see if the Nvision Imaging System (VLE) can accurately determine the risk of recurrent Barrett's esophagus in patients with Barrett's esophagus which have been clear of disease.


Patients with Barrett's Esophagus (BE) undergoing endoscopic therapy through our Barrett's Esophagus Unit will be approached for study enrollment. Patients with no endoscopic evidence of BE will be considered for the study. Surveillance biopsies will be obtained per standard clinical protocol and reviewed to confirm absence of intestinal metaplasia. Patients who have achieved complete eradication of intestinal metaplasia (CRIM) will be enrolled in the study and will undergo the Nvision Imaging System (VLE). Patients enrolled in the study will undergo clinical follow-up consisting of surveillance endoscopy every 3 months for 1 year. Surveillance endoscopy intervals may be prolonged to every 6 months in the second year, and annually thereafter. At each follow-up visit, endoscopic data will be collected to determine if patients remain in CRIM or show evidence of recurrent disease. Patients will be followed for 1 year (endpoint 1) and 3 years (endpoint 2).


Condition Barrett Esophagus
Treatment The Nvision VLE Imaging System
Clinical Study IdentifierNCT03670134
SponsorMayo Clinic
Last Modified on18 April 2022

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