Inflammation in Vascular Disease

  • End date
    Feb 1, 2024
  • participants needed
  • sponsor
    Göteborg University
Updated on 23 January 2021
cardiovascular disease
vascular surgery
heart disease


Increasing evidence suggests that systemic low-grade inflammation may be a driving force of cardiometabolic complications, such as vascular dysfunction, atherosclerosis and ischemic heart disease. Thus, we will investigate the role of inflammation in cardiovascular disease.


Vascular reconstruction surgeries usually require a small piece of the vessel wall to be excised. The excised vessel is generally discarded as medical waste: however, for patients participating in the study, the excised tissue will be placed in saline and collected for research use.

Tissue collected from individuals undergoing vascular surgery associated with peripheral arterial diseases, aneurysm and/or other manifestations of atherosclerosis, vascular tissue will be cultured ex vivo in the presence or absence of therapeutic agents, to determine if these attenuate the inflammation associated with the atherosclerotic phenotype. Furthermore, the protocol will also be carried out using vascular tissue from control patients, which have undergone vascular surgery that is not associated with vascular disease (e.g. knee replacement surgery, trauma, etc).

Condition Vascular Diseases, Vascular Diseases, Cardiovascular Disease, Cardiovascular Disease, Atherosclerosis, Atherosclerosis, Arteriosclerosis, Atherosclerotic Cardiovascular Disease, vascular disorder, vascular disease, vasculopathy, vasc
Clinical Study IdentifierNCT03732612
SponsorGöteborg University
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

Patient is planned to undergo vascular surgery
Signed informed consent has been obtained from the patient

Exclusion Criteria

Patient has difficulty to understand information
Patients under 18 years of age
Patients participating in any drug-related study
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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