Endoscopic Ultrasound-guided RadioFrequency Ablation for the Treatment Pancreatic NeuroEndocrine Neoplasms (RAPNEN)

  • STATUS
    Recruiting
  • participants needed
    70
  • sponsor
    Catholic University of the Sacred Heart
Updated on 10 June 2023
insulin
fasting
endoscopic ultrasound
metastasis
dotatate
pet/ct scan
pet-ct scan
local ablation therapy
fine needle biopsy

Summary

This study evaluates the possibility and the safety of performing local therapy for Pancreatic neuroendocrine neoplasms (PanNENs) using radiofrequency ablation of the tumor under ultrasonography (EUS) guidance.

Description

Pancreatic neuroendocrine neoplasms (PanNENs) are rare, but their incidence has significantly increased in the last decades. The mainstay treatment of PanNENs is surgery, which is associated with a significant benefit in term of survival but also with significant shortand long-term adverse events.

Based on the above data, less invasive alternative therapeutic interventions to avoid shortand long-term adverse events of surgery are needed.

In this context radiofrequency ablation has been reported to be effective in the treatment of these tumors in absence of major adverse events. However, the available studies on the matter are limited by small sample size and lack of standardized criteria for patient selection.

Details
Condition Neuroendocrine Tumors, Neuroendocrine Carcinoma, Pancreas Neoplasm, Neuroendocrine Tumor Gastrointestinal, Hormone-Secreting
Treatment EUS guided radiofrequency ablation
Clinical Study IdentifierNCT03834701
SponsorCatholic University of the Sacred Heart
Last Modified on10 June 2023

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