Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF (BCAA-ACLF)
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- STATUS
- Recruiting
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- days left to enroll
- 53
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- participants needed
- 68
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- sponsor
- Postgraduate Institute of Medical Education and Research
Summary
This study analyses the effect of intravenous branched chain amino acids (BCAA) on overt HE in patients with ACLF. The investigators plan to study the efficacy of combining intravenous BCAA with lactulose versus lactulose alone in the medical management of overt HE in patients with ACLF and its impact on overall survival and improvement in grade of HE.
Description
Acute on chronic liver failure (ACLF) is a distinct clinical entity in the spectrum of chronic liver disease associated with high short term mortality. Hepatic encephalopathy (HE) is commonly seen in patients with ACLF and its treatment mainly involves non-absorbable disaccharides (lactulose/lactitol).Treatment of HE in ACLF is based on extrapolation of data available from cirrhotic patients. No studies have compared different treatment options for HE in patients with ACLF.
Details
| Condition | Hepatic Encephalopathy, Acute-On-Chronic Liver Failure |
|---|---|
| Treatment | Lactulose, Branched chain amino acid |
| Clinical Study Identifier | NCT04238416 |
| Sponsor | Postgraduate Institute of Medical Education and Research |
| Last Modified on | 24 February 2022 |
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