The objective of this study are to evaluate the safety and tolerability of ABT-199
(venetoclax) in patients with advanced Cutaneous T cell lymphoma (CTCL). A secondary
objective is to explore clinical response to ABT-199 (venetoclax) in patients with advanced
This is a single arm, open-label, non-randomized study with venetoclax (ABT-199) in CTCL
patients (subtypes mycosis fungoides and Szary syndrome only, and excluding transformed
mycosis fungoides). This study is planned to be conducted in 18 patients, 18 years or older
in age, undergoing a 5-week dose escalation protocol (per the US FDA package insert
guidelines of venetoclax for CLL). Safety monitoring will continue throughout the whole
period of drug administration and the treatment will be discontinued if intolerable toxicity
(defined in Stopping Rules) or disease progression occurs during this period.
Clinical Study Identifier
Last Modified on
20 January 2021
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