Determinants of the Vascular Response to Training in Chronic Obstructive Pulmonary Disease (COPD) Patients (cDysEndoBPCO)

  • End date
    Jun 9, 2023
  • participants needed
  • sponsor
    University Hospital, Montpellier
Updated on 9 August 2022
Accepts healthy volunteers


Vascular comorbidities constitute a major burden in COPD patients. The atherosclerosis process is preceded by the onset of an endothelial dysfunction (assessed by the flow-mediated dilatation (FMD)), which is a risk factor for later ischemic vascular complications and death. In COPD, this endothelial dysfunction could be explained by intrinsic endothelial cell properties, or the effect of a pathogenic endothelial cell microenvironment (inflammation and/or oxidative stress). Exercise training constitue a powerful stimulus for the endothelial function, and could be mediated by the mobiliaztion and function of endothelial progenitors. While exercise training is an efficient intervention in COPD patients, its vascular effect appear blunted. The endothelial function response to training has appeared heterogeneous in COPD patients, and possibly linked to the endothelial cel lesion. Thus, endothelial function (assessed by the FMD) response to exercise training would be lower in COPD patients with a baseline impairment of the their FMD. In addition, of biological and functional factors could explained the magnitude of the FMD response in COPD patients.The aim of the study are thus :

To compare the FMD change in COPD patients with FMD above (FMD+) and under the median FMD (FMD-) after 4 weeks of exercise training in the whole study population.

To compare between COPD patients FMD+, COPD patients FMD- and healthy "control" subjects, the endothelial inflammation and senescence at baseline and the endothelial progenitor mobilization and function change induced by exercise (maximal exercise test and training).

To compare between COPD patients FMD+, COPD patients FMD- and healthy "control" subjects the effect of the endothelial microenvironment on the cellular pathways regulating the endothelial function in vitro at baseline and changes after exercise training.

To test in COPD patients the association between the magnitude of the FMD changes after training and biological, functional and clinical factors (inflammation oxidative stress markers, endothelial biomarkers, pulmonary impairment and phenotype, cardiovascular risks factors, vascular function, metabolic markers, physical activity level, …)

Condition COPD Patients, Healthy
Treatment FMD analysis
Clinical Study IdentifierNCT03774238
SponsorUniversity Hospital, Montpellier
Last Modified on9 August 2022


Yes No Not Sure

Inclusion Criteria

age between 35 and 85 years old
A/ COPD patients
spirometry showing an FEV1/VC < lower limit of normal
written and informed consent for this study signed by the patient
with an indication for a pulmonary rehabilitation program
B/ Healthy subjects
age between 35 and 85 years old
no cardiovascular or respiratory disease
normal spirometry

Exclusion Criteria

Unstabilized comorbidity
Subject in a period of exclusion relative to another protocol
Major protected by law
Subject participating in another research protocol
Subject not affiliated to a social security scheme
Pregnant or lactating woman
Patient deprived of freedom by court or administrative order
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