Pencil Beam Scanning in Patients With Renal Tumors

  • STATUS
    Recruiting
  • End date
    Aug 31, 2023
  • participants needed
    25
  • sponsor
    Children's Hospital of Philadelphia
Updated on 28 January 2021
sarcoma
beam radiation
nephroblastoma
anaplasia
renal neoplasm

Summary

This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.

Description

Patients with renal tumors including Wilms and clear cell sarcoma of the kidney (CCSK) are treated with multimodality therapy which may include surgery, chemotherapy, and radiation. While long-term disease control is excellent, these patients remain at risk for early and late toxicities partially from radiation. There have been no significant changes to traditional photon radiation fields, which encompass the post-operative bed, anterior abdomen, and vertebral body. Proton beam radiation using pencil beam scanning, which is characterized by Bragg peak dose deposition and high conformality of dose to target regions, is ideally suited to treat the retroperitoneum. This pilot study evaluates pencil beam scanning proton therapy (PBS-PT) to:

  • result in low acute gastrointestinal toxicity in patients receiving radiation therapy for renal tumors as measured by laboratory evaluations, clinician-assessed, and patient reported health related quality of life outcomes
  • decrease the duration of radiation therapy
  • compare doses to organs at risk (OARs) using PBS-PT as compared to traditional photon fields

Details
Condition Malignant neoplasm of kidney, Hereditary Neoplastic Syndrome, Nephroblastoma, Kidney Cancer, Wilms' Tumor, Hereditary Cancer Syndromes, Renal Cancer, kidney tumor, renal tumors, neoplasia renal, renal neoplasm, renal tumor, kidney tumours, kidney tumors
Treatment Proton beam radiation using pencil beam scanning
Clinical Study IdentifierNCT03810651
SponsorChildren's Hospital of Philadelphia
Last Modified on28 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age less than or equal to 30 yrs?
Gender: Male or Female
Do you have any of these conditions: Kidney Cancer or Malignant neoplasm of kidney or Hereditary Cancer Syndromes or Wilms' Tumor or Nephroblastoma or Renal Cancer or Hereditary Neoplasti...?
Do you have any of these conditions: Hereditary Cancer Syndromes or Wilms' Tumor or Malignant neoplasm of kidney or neoplasia renal or kidney tumours or renal tumors or renal neoplasm or ...?
Do you have any of these conditions: kidney tumors or Nephroblastoma or kidney tumours or Renal Cancer or neoplasia renal or renal tumors or Hereditary Cancer Syndromes or renal neoplasm ...?
Less than 30 years of age
Diagnosis
Any patient with Wilms tumor or clear cell sarcoma of the kidney who would require radiation therapy as standard of care including
Any patient with favorable histology (FH), stage III disease
Any patient with focal or diffuse anaplasia
Any patient with CCSK
The patient is a candidate for external beam radiotherapy based on standard of care for treatment of Wilms tumor or CCSK

Exclusion Criteria

Prior radiotherapy to the region of the study cancer
Chemotherapy administered for diagnosis of Wilms tumor or CCSK
Pregnant or breastfeeding
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