Using Neuroeconomics to Characterize State-Based Increases and Decreases in Alcohol Value

  • STATUS
    Recruiting
  • days left to enroll
    29
  • participants needed
    80
  • sponsor
    McMaster University
Updated on 4 July 2022
heavy drinking
addiction
functional magnetic resonance imaging
Accepts healthy volunteers

Summary

This study uses techniques from an area of research known as neuroeconomics, which integrates concepts and methods from psychology, neuroscience, and economics to better understand how people make decisions and how these decisions are supported by the brain. One neuroeconomic concept that is especially relevant in the area of addictions is substance demand, or how consumption of a commodity (e.g., alcohol, tobacco, or drugs) is influenced by price and other factors. Previous studies have shown that alcohol demand is related to severity of alcohol misuse, drinking quantity/frequency, and treatment outcomes. In addition, we know that alcohol demand can also fluctuate in response to environmental cues such as alcohol-related stimuli or external contingencies such as important responsibilities the following day. These increase and decreases in consumption and value are clinically significant because they help us understand how people with alcohol use disorders are able to successfully or unsuccessfully modulate their drinking behaviors. This study is examining how the brain responds in these situations and whether these responses differ as a function of severity of alcohol misuse. This study will use functional magnetic resonance imaging (fMRI) to understand brain activity patterns associated with changes in the value of alcohol in the presence of alcohol-related beverage cues relative to neutral-related beverage cue. Participants will be non-treatment-seeking adult heavy drinkers who are recruited from the community to participate in an fMRI scan. During the scan, participants will make decisions about how many alcohol beverages they would consume (hypothetically) at various prices while their brain activity during those decisions is measured. The first experimental manipulation involves an in-scanner alcohol cue exposure task in which the drinking decisions will be made after viewing high-quality images of alcoholic (beer/wine/liquor) beverages or neutral (water/juice/soft drinks) beverages.

Description

Neuroeconomics integrates concepts and methods from psychology, economics, and cognitive neuroscience to understand the neurobiological foundations of decision making, and has been increasingly applied to understanding alcohol use disorder (AUD). A novel application of neuroeconomics is the study of alcohol demand, or the value of alcohol as measured by cost-benefit preferences. Alcohol demand paradigms have considerable ecological validity by measuring the impact of internal and external influences on alcohol decision-making, such as price, environmental cues, affective states, or external contingencies. Behaviorally, alcohol demand is elevated among individuals with higher levels of alcohol misuse and predicts treatment response. Alcohol demand also exhibits state-like properties, including increases following exposure to alcohol-related cues. The overall goal of the proposed studies is to characterize the neural activity that subserves these established behavioral findings using a novel functional MRI paradigm.

The primary aim is to examine the patterns of neural activation underlying increases in the value of alcohol in response to alcohol cues. To do so, the first study will use a within-subjects design to identify differences in neural activity associated with demand decisions following a validated in-scanner cue exposure protocol consisting of exposure to neutral beverage cues and exposure to alcohol beverage cues in a sample of adult heavy drinkers.

Using a novel neuroeconomics approach, this study combines a highly ecologically-valid alcohol demand paradigm with two experimental manipulations that model clinically-relevant influences on drinking decisions. Studying these contextual influences may help clarify the neural signatures that underlie drinking moderation vs. unconstrained drinking, and how these processes are impacted by AUD. If successful, these studies will provide a foundation for examining neural predictors of successful recovery or response to treatment vs. relapse. More broadly, findings from this study have high potential to significantly enhance the clinical relevance of alcohol neuroscience.

Details
Condition Alcohol Use Disorder, Alcohol Drinking
Treatment Neutral cue, Alcohol vs Neutral Cue, Responsibility vs No Responsibility, Alcohol cue
Clinical Study IdentifierNCT04067765
SponsorMcMaster University
Last Modified on4 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

-55 years old
Right-handed
Fluent English speaker
Heavy drinker (i.e., on average > 14/7 drinks per week for males/females in past three months
Average of 1 heavy drinking episode weekly (heavy drinking episode = 5+/4+ for males/females) over past three months

Exclusion Criteria

Currently receiving treatment, or seeking treatment, for alcohol related problems
Current Diagnostic and Statistical Manual (DSM-5) substance use disorder other than alcohol or tobacco
Weekly or more frequent use of recreational drugs
History of schizophrenia-spectrum disorders, psychotic disorders, bipolar disorder, or PTSD
History of neurocognitive disorder or impairment
MRI contraindications (e.g., metal in body, history of seizure, etc.)
History of serious brain injury
Currently taking psychotropic medications or medications that could affect cerebral blood flow
Pregnancy (females)
Attending any study session with a positive breath alcohol concentration (BrAC > 0.00g%)
Clear my responses

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