Addition of Chidamide to the Combination Treatment of Decitabine Plus Camrelizumab in Combination Treatment Resistant/Relapsed Patients With Classical Hodgkin Lymphoma

  • End date
    Feb 25, 2026
  • participants needed
  • sponsor
    Chinese PLA General Hospital
Updated on 24 February 2022
cell transplantation
classical hodgkin lymphoma
refractory hodgkin lymphoma


This is a Phase II clinical trial for Decitabine plus Camrelizumab resistant/relapsed patients with Hodgkin Lymphoma. The purpose is to evaluate the efficacy and safety of the combination therapy of Chidamide plus Decitabine Plus Camrelizumab.

Condition Hodgkin Lymphoma
Treatment Decitabine, Chidamide, Camrelizumab
Clinical Study IdentifierNCT04233294
SponsorChinese PLA General Hospital
Last Modified on24 February 2022


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Inclusion Criteria

Subjects must have histological confirmation of relapsed or refractory Hodgkin lymphoma (HL)
12 to 75 years of age
ECOG performance of less than 2
Life expectancy of at least 3 months
Subjects with lymphoma must have at least one measureable lesion >1 cm as defined by lymphoma response criteria
Subjects must be relapsed or resistant for the treatment of Decitabine plus Camrelizumab. Subjects with autologous hematopoietic stem-cell transplantation are eligible which must be more than 3 months
Subjects must have adequate marrow, live, renal and heart functions

Exclusion Criteria

Subjects with any autoimmune disease or history of syndrome that requires corticosteroids or immunosuppressive medications
Serious uncontrolled medical disorders or active infections, pulmonary infection especially
Active alimentary tract hemorrhage or history of alimentary tract hemorrhage in one month
Prior organ allograft
Women who are pregnant or breastfeeding
Women with a positive pregnancy test on enrollment or prior to investigational product administration
Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness
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