The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group.
We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.
The investigators aim to recruit participants with regular racing pigeon exposure at national (UK) and regional pigeon fancier meetings.
Consenting subjects will complete questionnaires, provide blood samples for genetic analysis and immunological testing and undertake lung function measurements.
Subjects will be observed, and encouraged to report referral to specialist respiratory services, and following this information will be sought on diagnosis (including supporting evidence). Where interstitial lung disease is detected this will be linked to subsequent unbiased analysis to detect potential predisposing genetic associations.
| Condition | Lung; Disease, Interstitial, With Fibrosis, Alveolitis, Extrinsic Allergic, Bird Fancier's Lung, Idiopathic Interstitial Pneumonias, Lung Diseases, Interstitial, Idiopathic Pulmonary Fibrosis |
|---|---|
| Treatment | Genetic profiling |
| Clinical Study Identifier | NCT03747627 |
| Sponsor | University of Dundee |
| Last Modified on | 27 June 2022 |
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