Neuroimmune Response to Lipopolysaccharide

  • End date
    Apr 30, 2022
  • participants needed
  • sponsor
    Yale University
Updated on 1 May 2021


In this study, healthy adult volunteers will undergo two positron emission tomography (PET) scans using the radiotracer [11C]PBR28 which binds to the 18kDa translocator protein (TSPO). Approximately 3 hours prior to the second [11C]PBR28 PET scan, lipopolysaccharide (LPS; endotoxin) will be administered to evoke a robust neuroimmune response. Subjects will also undergo behavioral and cognitive testing. Vital signs, subjective response, and peripheral cytokine levels will be assayed periodically throughout the experimental session.

Specific aims: Quantify the magnitude of neuroimmune response after a classical immune stimulus.

Secondary aims: Quantify changes in cognitive function after a classical immune stimulus.

Hypothesis: Individuals will exhibit a robust whole-brain neuroimmune response and impaired cognitive function after LPS.

Condition healthy
Treatment Lipopolysaccharide
Clinical Study IdentifierNCT04233593
SponsorYale University
Last Modified on1 May 2021


Yes No Not Sure

Inclusion Criteria

Medically-healthy male and female subjects able to read/write English

Exclusion Criteria

Subjects cannot meet DSM criteria for substance use disorder
Any psychiatric symptoms that could put the subject at risk by participating in the study including but not limited to suicidal or homicidal ideation, or suicide attempt within the last year
Pregnancy or breastfeeding
Any current medical illness that could put the subjects at risk during the PET scan, or interfere with the PET or immunologic measures
Significant hepatocellular injury (as evidenced by AST or ALT levels greater than 5 times normal or a history of cirrhosis) will be exclusionary in order to reduce the risks associated with alcohol consumption
Subjects taking corticosteroids or other immunosuppressant drugs
Subjects with disorders affecting the brain, including but not limited to multiple sclerosis, history of stroke, brain tumors, intracranial bleeding, infection, or abscess
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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