The purpose of this study is to better understand mental illness and will test the hypotheses
that while viewing affective stimuli, patient groups will show increased blood oxygenation
level dependent (BOLD) signal by fMRI after lorazepam.
This study will enroll participants between the ages of 16 and 60, who have a psychotic
illness (such as schizophrenia, bipolar disorder, and schizoaffective disorder). The study
will also enroll eligible participants without any psychiatric illness, to compare their
The study will require participants to have 3-4 sessions over a few weeks. The first session
(may be over two visits) will include a diagnostic interview and several questionnaires
(qols) to assess eligibility. Subsequently, there will will be two separate functional
magnetic resonance imaging (fMRI) sessions in which lorazepam or placebo will be given prior
to the MRI. During the fMRI the participants will also be asked to answer questions.
Additionally, the participants will have their blood drawn, women of child bearing potential
will have a urine pregnancy test, vital signs taken, and asked to complete more qols.
Please note the collaborator (NIMH) is requesting that an NCT number be obtained prior to
receiving the award number.
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.